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However, the stopcodon is preceded by a run of 11 consecutive adenosines.
2
The single-base pair mutation causes a frameshift, which results in premature stopcodon.
3
This duplication results in a frame shift and premature stopcodon.
4
A premature stopcodon UGA appeared to be most responsive to PTC124 treatment.
5
The 5'UTR contains two false AUG initiation codons followed by a stopcodon.
Usage of termination codon in English
1
The remainder of the sequence corresponded to the 3'-region of the mRNA downstream from the terminationcodon.
2
Furthermore, the most C-terminally located premature terminationcodon mutation fails to rescue the progenitor cell proliferation defect in hippocampal slice cultures from Bcl11b-deficient mice.
3
RNA analysis revealed that an alternative splice site within exon 1 was used leading to a premature terminationcodon within exon 2.
4
Affected animals carry a mutation that predicts a premature terminationcodon in exon 8 and a peptide that is 5% the size of normal dystrophin.
5
Due to premature terminationcodons, none encodes functional protein.
6
These cytoplasmic introns were found to be highly conserved and introduced premature terminationcodons into coding regions.
7
The mutation was associated with two shortened transcripts, both with shifted reading frames resulting in premature- terminationcodons.
8
The presence of terminationcodons in all three reading frames suggests that the common region probably does not contain coding sequences.
9
We found that one-third of the alternative transcripts examined contain premature terminationcodons, and most persist even after rigorous filtering by multiple methods.
10
Finally, our analyses suggested that premature terminationcodons in selenoprotein genes trigger nonsense-mediated decay, but do this inefficiently when UGA codon is gained.
11
The majority of these mutations result in premature terminationcodons that would be predicted to trigger nonsense-mediated decay (NMD) of mutant mRNA and cause haploinsufficiency.
12
A total of 11 disease-causing WNT1 variants (7 missense mutations, 4 mutations leading to premature terminationcodons) were identified, of which 9 were novel.